Silverex

Assistance IN Preventing Transmission of Infectious Agents in Health Care, Related to Corona virus (COVID-19 )

Free from Alcohol, Acids, Harsh chemicals and Nascent Oxygen.
Natural, Nontoxic, Non carcinogenic.
FOR EXTERNAL APPLICATION ONLY

Contains Nanoparticles of Silver 100 ppm.

  • The coronavirus is spread through sustained contact with “viral droplets” from an infected person’s coughs or sneezes.

  • Current evidence suggests that novel coronavirus may remain viable for hours to days on surfaces made from a variety of materials.
  • Cleaning of visibly dirty surfaces followed by disinfection is a best practice measure for prevention of COVID-19 and other viral respiratory illnesses in households and community settings.
  • Each individual may protect himself with Face masks, Gloves and Hand sanitizers.
  • Also all confined places, places packed with human population like Trains, Bus, Movie Theaters, Function halls, Assembly, and others to decontaminate the entire Area by spraying/fogging/drenching in a disinfection tunnel etc.
  • For Better protection, Facemasks and Gloves can be either Bioxcell
  • Life Sciences Pvt. Ltd.,impregnated with Silverex Silver by manufacturers or each individual may spray on the mask while using.
  • Preventing precautions are to be continued until this virus is totally contained.

Coronaviruses (CoV) belong to the genus Coronavirus in the Coronaviridae. All CoVs are pleomorphic RNA viruses characteristically containing crown-shape peplomers with 80-160 nM in size and 27-32 kb positive polarity. Recombination rates of CoVs are very high because of constantly developing transcription errors and RNA Dependent RNA Polymerase (RdRP) jumps. With its high mutation rate, Coronaviruses are zoonotic pathogens that are present in humans and various animals with a wide range of clinical features from asymptomatic course to requirement of hospitalization in the intensive care unit; causing infections in respiratory, gastrointestinal, hepatic and neurologic systems.

Disadvantages of using Alcohol

When used too frequently, alcohol-based hand sanitizers can wash away your skin’s natural oils, which can cause drying and cracking. Dehydrated skin can be unattractive and irritating, and it is likely to cause one or more of the following symptoms:

  • Itching

  • Slight to severe flaking, scaling, or peeling
  • Fine lines or cracks
  • Gray, ashy skin color
  • Redness
  • Deep cracks that may bleed
  1. Dry, cracked cuticles and skin can offer an entry point for germs to enter the body and cause infection. In addition, if you’re prone to eczema, excessive dryness can activate the disease, causing redness, cracking, and inflammation. 

  2. They can disturb the natural pH and barrier of the skin, leaving skin vulnerable to allergens which can penetrate beneath the surface and trigger an autoimmune reaction. It is this reaction which causes reddening, itching, blisters, swelling, peeling, and cracking.
  3. Using alcohol based hand sanitizers may actually lower your resistance to diseases by killing good bacteria, which helps protect against bad bacteria.
  4. They could theoretically lead to antibacterial resistance.
  5. Health effects for alcohol-based hand sanitizers were ocular irritation, vomiting, conjunctivitis, oral irritation, cough, and abdominal pain.
  6. Over-washing with alcohol-based hand sanitizers  can cause hands to dry out, crack and bleed, which allows germs to enter the body.
    7. Despite the wide use of alcohol-based disinfectants, E. faecium like pathogens which acquire drug resistance, are now a leading cause of hospital-acquired infections.
    8. A sanitizer with 62 percent ethyl alcohol is equivalent to a 120-proof drink. The alcohol in sanitizers is usually poisonous and can damage the liver and nervous system.
    9. Rare effects included coma, seizure, hypoglycemia, metabolic acidosis, and respiratory depression.

Silver Nanoparticles

Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, Nano scale materials have emerged as novel antiviral agents for the possibilities offered by their unique chemical and physical properties. Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses including human immunodeficiency virus, hepatitis B virus, herpes simplex virus, respiratory syncytial virus, and monkey pox virus. The use of metal nanoparticles provides an interesting opportunity for novel antiviral therapies. Since metals may attack a broad range of targets in the virus there is a lower possibility to develop resistance as compared to conventional antivirals. The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264685/)

Respiratory Syncytial Virus (RSV) is the leading cause of severe respiratory illnesses including bronchiolitis and pneumonia in young children. In this project, we utilized silver nanoparticles conjugated to various proteins, as well as poly lactic acid, to study the inhibition of RSV infection in cell culture. We selected poly(N-vinyl-2-pyrrolidone) (PVP), recombinant RSV fusion (F) protein, and Bovine Serum Albumin as chemical conjugates with silver nanoparticles. These nanoparticles were analyzed using transmission electron microscopy. After the cytotoxicity of each of the nanoparticle conjugates was established using the Trypan Blue Exclusion Assay, they were mixed with RSV and added to HEp-2 cells. The effectiveness of RSV inhibition was then evaluated by microscopic examination for syncytia formation and by immunofluorescence microscopy. Our results revealed that PVP-coated silver nanoparticles, which showed low toxicity to cells at low concentrations, inhibited RSV infection by 44%, a significant reduction compared to other controls. In this project, we researched the effectiveness of silver nanoparticles for the inhibition of RSV infection. Based on our results, PVP-coated silver nanoparticles seem to be a promising candidate for future RSV treatment research in animal models.

(https://www.researchgate.net/publication/233505657_Silver_Nanoparticles_Inhibit_Replication_of_Respiratory_Syncytial_Virus)

Argovit is a drug based on silver nanoparticles and developed by TPU scientists jointly with their partners. The drug is successfully tested in veterinary medicine for the treatment of domestic animals. Thus, veterinarians in Mexico proved the high efficiency of Argovit for the treatment of canine distemper in dogs. Veterinarians have already cured 13 sick pets.

(https://tpu.ru/en/about/tpu_today/news/view?id=3084)

Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses including human immuno deficiency virus, hepatitis B virus, herpes simplex virus, respiratory syncytial virus, and monkey pox virus. The use of metal nanoparticles provides an interesting opportunity for novel antiviral therapies. Since metals may attack a broad range of targets in the virus there is a lower possibility to develop resistance as compared to conventional antivirals. The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264685/)

Exposures to the surfaces of Ag/Al2O3 and Cu/Al2O3 destroy the replication and propagation abilities of SARS-CoV, baculovirus and E. coli. Inactivation ability of metal catalysts needs to interact with air, utilizing oxygen molecules in air. Efficiently killing viruses and bacteria on the surfaces of the two metal catalysts has a promising potential for air-disinfection in hospitals, communities, and households.

(https://www.ncbi.nlm.nih.gov/pubmed/16131020

SAFETY OF SILVER NANOPARTICLES

Unlike other metals such as lead and mercury, silver is not toxic to humans and is not known to cause cancer, reproductive or neurological damage, or other chronic adverse effects. Nor has normal day-to-day contact with solid silver coins, spoons or bowls been found to affect human health.

In vivo acute/sub acute toxicity data showed no changes in mice health status after intraperitoneal administration. Histological observations of internal organs and the biochemical parameters analyzed together with the other biological observations showed a low toxicity level with no major differences related to control, albeit at skin level a reduced number of mast cells was detected 
[Stensberg M.C., Wei Q., McLamore E.S., Porterfield D.M., Wei A., Sepulveda M.S. Toxicological studies on silver nanoparticles: Challenges and opportunities in assessment, monitoring and imaging. Nanomedicine. 2011;6:879–898. doi: 10.2217/nnm.11.78.].

SALIENT FEATURES OF SILVEREX SILVER

  • It can kill Pathogens, Fungi, Yeast and Virus
  • Can help in wound healing, if present
  • It will not cause drug resistance.
  • Dose rate is minimal.
  • Sustained protection till it is removed by washing with water/bathing.
  • No side effects noticed.
  • Same product can be used in many applications like; to rub on hands/Spray on any particular surface/Fog an entire area/in disinfection tunnels.

How to clean and disinfect for protection by Prevention:

Spray on the Inner and outer Facemask, Inner and outer Gloves, Scrub Hands and leave without wiping.

Spray on Hands:
2-3 puffs if sprayed. 
If Loose quantity used, you may use upto 2 ml.

Use in disinfection tunnel:

Silverex AgNP 250 ppm can be used for tunnel disinfection by misting through nozzles fit it the tunnel

·      A tunnel consists of 8 nozzles
·      1 L of liquid is misted through nozzles every 1 hour
·      Total liquid misted in a tunnel : 8 nozzles x 1 L = 8 L
·      Silverex AgNP dose : 10 ml / L water
·      Silverex AgNp dose for one tunnel : 10 ml / L x 8 L = 80 ml / tunnel/ hour
·      No of people walking through the tunnel in 1 minute : 6
·      No of people walking through the tunnel in 1 Hour : 6 x 60 = 360 people 
·      Therefore 80 ml Silverex AgNP is misted on 360 people in 1 hour
·      Quantity of Silverex AgNP per person ( assuming 70 Kg  average body weight ) : 80 / 360 = 0.22 ml / person
·      Quantity of Silverex AgNP per Kg body weight : 0.22 ml / 70  Kg = 0.00314 ml OR 3.14 micro Litre / kg body weight
·      Quantity of silver per person :
·      Silverex AgNP has 250 ppm / L silver nano particles  : 0.25 mg/ml
·      80 ml Silverex AgNP has : 0.25 x 80 = 20 mg silver
·      20 mg silver is misted on 360 people
·      Quantum of silver misted per person : 20mg  / 360 = 0.0555 mg  per person

Summary

1.      Quantum of silver nano particle misted per person :0.0555 mg 
2.      Quantity of Silverex AgNP per person misted ( assuming 70 kg body weight): 0.22 ml
3.      Quantity of SIlverex AgNP per Kg body weight(assuming 70 kg body weight) : 3.14 micro gram

While Fogging, 
FACTORIES, RAILWAY STATIONS, AIR PORTS, TRANSPORT VEHICLES, HOSTELS, RESTAURENTS, CINEMA HALLS, TEMPLES, MALLS, SUPER MARKETS, VEGETABLE/FISH MARKETS AND PLACES WHERE HEAVY TRAFFIC IS EXPECTED:
Dilute with water in 1:20 ratio. Once in 12 hours preferred.

While Fogging, 
POULTRY AND CATTLE SHEDS
Dilute with water in 1:100 ratio. Once in 48 hours preferred.

Use In Floor Mopping and Toilet Seat Cleansing 
@ 4 ml/L

Use in Laundry 
@ 3 ml/5 L water

How to clean and disinfect when dealing with people positive with COVID-19:

Surfaces

  • Wear disposable gloves when cleaning and disinfecting surfaces. Gloves should be discarded after each cleaning. If reusable gloves are used, those gloves should be dedicated for cleaning and disinfection of surfaces for COVID-19 and should not be used for other purposes. Consult the manufacturer’s instructions for cleaning and disinfection products used. Clean hands immediately after gloves are removed.

  • If surfaces are dirty, they should be cleaned using a detergent or soap and water prior to disinfection.

    • Diluted Silverex Silver solutions can be used if appropriate for the surface. Check to ensure the product is not past its expiration date. Never mix Silverex Silver with ammonia or any other cleanser. Unexpired household bleach will be effective against coronaviruses when properly diluted.

      • Prepare a bleach solution by mixing:

        • 20 ml Silverex Silver per Liter water

  • For soft (porous) surfaces such as carpeted floor, rugs, and drapes, remove visible contamination if present and Spray before laundry or leave as it is after spray:

 Clothing, towels, linens and other items that go in the laundry

  • Wear disposable gloves when handling dirty laundry from an ill person and then discard after each use. If using reusable gloves, those gloves should be dedicated for cleaning and disinfection of surfaces for COVID-19 and should not be used for other household purposes. Clean hands immediately after gloves are removed.

    • If no gloves are used when handling dirty laundry, be sure to wash hands afterwards.

    • If possible, do not shake dirty laundry. This will minimize the possibility of dispersing virus through the air.

    • Launder items as appropriate in accordance with the manufacturer’s instructions. If possible, launder items using the warmest appropriate water setting for the items and dry items completely. Dirty laundry from an ill person can be washed with other people’s items.

    • Clean and disinfect clothes hampers according to guidance above for surfaces. If possible, consider placing a bag liner that is either disposable (can be thrown away) or can be laundered.

Hand hygiene and other preventive measures

  • Household members should clean hands often, including immediately after removing gloves and after contact with an ill person, by washing hands with soap and water for 20 seconds. If soap and water are not available and hands are not visibly dirty, hands may be scrubbed with Silverex Silver. However, if hands are visibly dirty, always wash hands with soap and water.

  • Household members should follow normal preventive actions while at work and home including recommended hand hygiene and avoiding touching eyes, nose, or mouth with unwashed hands.

    • Additional key times to clean hands include:

      • After blowing one’s nose, coughing, or sneezing

      • After using the restroom

      • Before eating or preparing food

      • After contact with animals or pets

      • Before and after providing routine care for another person who needs assistance (e.g. a child)

(Based on the guidelines of CDC

https://www.cdc.gov/coronavirus/2019-ncov/community/home/cleaning-disinfection.html)

References:

https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1307208

https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200202-sitrep-13-ncov-v3.pdf?sfvrsn=195f4010_6

https://nanolife.in/popup/AV-KIT-explaination.pdf

https://www.mdpi.com/1420-3049/16/10/8894/pdf

https://www.tandfonline.com/doi/full/10.1080/21691401.2017.1307208

NewsEdge, “University study shows ionic silver effective against SARS; supports previous research findings on SARS virus,” in BioPortfilio by AgION Technologies, 2005.

S. Z. Hamdani, “Study Shows Silver Nanoparticles Attach to HIV-1 Virus,” October 2005.

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